Partial regulation of serotonin transporter function by γ-synuclein
نویسندگان
چکیده
منابع مشابه
Structure, function and regulation of the 5-hydroxytryptamine (serotonin) transporter.
The serotonin transporter (SERT), which terminates serotonergic neurotransmission by rapid re-uptake of 5-hydroxytryptamine (5-HT) back into the nerve terminal was the subject of two studies. First, the regulatory effects of antidepressants on the expression of SERT was investigated. After chronic exposure of SERT to antidepressants, substrate transport and antidepressant binding parameters wer...
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With the aim of exploring the relationship between the serotonin transporter (5-HTT or SERT) and the activity level of serotonin (5-HT) neurotransmission, in vivo expression of this protein was specifically altered using a nonviral DNA transfer method. Plasmids containing the entire coding sequence or a partial antisense sequence of the 5-HTT gene were complexed with the cationic polymer polyet...
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The serotonin transporter (SERT) plays a critical role in the maintenance of normal neurotransmission by serotonin [5-hydroxytryptamine (5-HT)]. Recent evidence suggests that SERT and other neurotransmitter transporters are tightly regulated. Activation of protein kinase C results in a decrease in SERT-mediated 5-HT uptake, which is due to an internalization of the transporter. However, to date...
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August 2010 Volume 10, Issue 4 T he serotonin transporter (SERT) on platelets is a primary mechanism for serotonin (5HT) uptake from the blood plasma. Alteration in plasma 5HT level is associated with a number of cardiovascular diseases and disorders. Therefore, the regulation of the transporter’s activity represents a key mechanism to stabilize the concentration of plasma 5HT. There is a bipha...
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OBJECTIVE While evidence for oxidative injury is frequently detected in brains of humans affected by Parkinson's disease (PD) and in relevant animal models, there is uncertainty regarding its cause. We tested the potential role of catalase in the oxidative injury that characterizes PD. METHODS Utilizing brains of A53T α-Syn and ntg mice, and cultured cells, we analyzed catalase activity and e...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2009
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2009.02.033